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Vol. 40. Issue 4.
Pages 425-426 (October - December 2020)
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Vol. 40. Issue 4.
Pages 425-426 (October - December 2020)
Letter to the Editor
Open Access
Diagnosis and treatment of constipation: A clinical update based on the Rome IV criteria
Diagnóstico e tratamento da constipação: uma atualização clínica com base nos critérios de Roma IV
Rafael Luís Luporini
Corresponding author

Corresponding author.
, André Lanza Rizzo, Sthefânia Mendonça Frizol, Luciana Ditomaso Luporini
Universidade Federal de São Carlos, Departamento de Medicina, São Carlos, SP, Brazil
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Dear Editor,

Recently, a review article entitled “Diagnosis and treatment of constipation: a clinical update based on the Rome IV criteria” was published. It is a broad and updated review of the literature on constipation, including the details of its pathophysiology, diagnosis, and treatment. The objective of Sobrado and colleagues1 was to evaluate the current guidelines published by professional associations on the diagnosis and treatment of functional constipation in adults and compare these guidelines with the authors' clinical experience.

The online search for bibliographic references was performed in the Medline/PubMed, Scielo, EMBASE, and Cochrane databases considering the terms: chronic constipation, diagnosis of intestinal constipation, management of chronic constipation, Rome IV, and surgical treatment of constipation. The authors conclude that the critical evaluation of the specialist physician responsible for the action plan to be conducted according to the clinical status of the patient is sovereign in relation to the information contained in the article.

Considering this review article of great relevance to the clinical and surgical study and management of functional intestinal constipation, we would like to respectfully add a contribution to this article highlighting an important aspect of the etiology of the disease that must be rectified.

Regarding the possible etiologies of secondary intestinal constipation, hypoparathyroidism was cited by the authors. However, after extensive search in the same databases included in the methodology described in the article, with the keywords intestinal constipation and hypoparathyroidism, no evidence was found of the relationship between these two dysfunctions.

The etiology of intestinal constipation is multifactorial and may include factors ranging from diet, medication use, neurological, and psychosocial disorders, and endocrinometabolic causes.2–5

Bharucha et al. (2020),3 in their important study on the subject, present hypothyroidism and hyperparathyroidism as endocrine and metabolic causes for intestinal constipation, contrary to hypoparathyroidism, mainly due to hypercalcemia, since calcium acts directly on intestinal motility favoring the coordination of peristaltic movements, molecular transport through the intestinal mucosa, and in the evacuation reflexes.

Hypoparathyroidism is a metabolic disorder due to a failure of the parathyroid glands to secrete parathormone (absence or inappropriately low concentrations), generating hypocalcemia and hyperphosphatemia, which has as gastrointestinal consequence diarrhea.6–8

Hypoparathyroidism is related to diarrhea, steatorrhea, and intestinal malabsorption syndrome, not being considered an etiological component for intestinal constipation, but hyperparathyroidism.9,10

We respectfully thank the authors for their initiative to review the literature and contrast it with their substantial clinical experience in the subject that can certainly contribute to the standardization of procedures, the aid of clinical reasoning and decision making by medical professionals.

Conflict of interest

The authors declare no conflict of interest.

C.W. Sobrado, I.J.F.C. Neto, R.A. Pinto, L.F. Sobrado, S.C. Nahas, I. Cecconello.
Diagnosis and treatment of constipation: a clinical update based on the Rome IV criteria.
J. Coloproctology, 38 (2018), pp. 137-144
A.E. Bharucha, A. Wald.
Chronic Constipation.
Mayo. Clin. Proc., 94 (2019), pp. 2340-2357
A.E. Bharucha, B.E. Lacy.
Mechanisms, Evaluation, and Management of Chronic Constipation.
Gastroenterology, 158 (2020),
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Constipation: pathophysiology and current therapeutic approaches.
Handbook of Experimental Pharmacology, (2016), pp. 59-74
S.S.C. Rao, K. Rattanakovit, T. Patcharatrakul.
Diagnosis and management of chronic constipation in adults.
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B.L. Clarke, E.M. Brown, M.T. Collins, H. Jüppner, P. Lakatos, M.A. Levine, et al.
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J. Clin. Endocrinol. Metab., 101 (2016), pp. 2284-2299
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J. Clin. Gastroenterol., 44 (2010), pp. 479-482
B. Abboud, R. Daher, J. Boujaoude.
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Journal of Coloproctology
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